COLLOIDAL ORGANIC SILICON

Si-Glycan-3

 

Laboratoires Glycanmétal

GLYCANMETAL Iberica and GLYCAN PHARMA Switzerland S.A. exercise 5 distinct activities.

1 Manufacture of all trace elements as hydrates, hydroxides and gluconates, which are the forms that the human body can use, and also production of colloidal organic silicon. The companies have European approvals for fine chemistry and raw material production for use human nutrition.

2 Clinical analysis using Urinary Atomic Metallograms and Atomic Matrix Imagery (UAM / AMI). Hair Atomic Metallogram (toxicological) (HAM) and Whole Blood Atomic Metallogram (WBAM). Lanthanides (rare earths) analysis in serum. They have developed the QUELATORR protocol that dechelates heavy and toxic metals. The laboratories have European approval for clinical analysis.

3 Analysis of dioxins, furans, PCBs and pesticides in biological fluids or at an industrial level.

4 Research into quantum medicine, nano- and micro-nutrition (glycan-proteins).

5 Nano-biotechnologies (proteins and genome)

Glycan Group :

1) Research with bio-environmental impact.
2) Clinical analyses.
3) Chemical analyses.
4) Chemical and toxicological expertise.
5) Methods intended for use in quantum medicine.
6) Manufacture of nano- and micro-nutrition products.
7) Plasma technologies.
8) Engineering of industrial de-pollution.
9) Scientific instrumentation.

THE TEAM (Research workers, Doctors, Pharmacists):

The laboratories are managed by the President of the GLYCAN group, Prof. Dr. Christian Daniel ASSOUN bio-physician. Christian Daniel ASSOUN co-founded the concept of Quantum Medicine (1979) with Doctor Lambin DOSTROMONT (doctor of medicine). He is also specialized in High Temperature Chemistry (Plasma Technologies) and membrane mechanisms (glycan-proteins), lanthanides, metal and metalloids involved in protein synthesis.

1 - SILICON'S BIOLOGICAL ROLE
Silicon is the most widely found metalloid on the planet as it represents 28% of the earth's crust.

It was thought to be a trace element for many years but research during the last twenty years has shown that it is in fact a secondary macro-element. Here’s a quick reminder of these major elements:

Macro-elements:
Sodium (Na), Potassium (K), Phosphorous (P), Calcium (Ca), Magnesium (Mg)

Secondary macro-elements:
 Silicon (Si), Boron (B), Bromine (Br), Rubidium (Rb), Strontium (Sr)

The amount of silicon in the body is about 7 grams, almost twice the amount of iron which shows its importance at a biological and structural level.

It is found virtually everywhere including in the blood (about 10 mg /liter equal to one tenth of the calcium level) and the organs and tissues: bone, blood vessel walls, spleen, tendons, muscles, liver, pancreas, kidneys, heart, endocrine system, eyes, skin... it is also present in the heart of the smallest biological cell because it contains three centrioles made of silicon.

The very high levels of silicon in the fetus reduces with age to such an extent that extra-cellular levels can be reduced by as much as 80 % in elderly people.

Silicon is poorly available in its non-soluble form (colloidal) but at about 10 % a non-specialized protein actively transports it. Furthermore, even in its organic form, i.e. the atypical acid Si(OH)4 is changed by replacing one hydroxyl (OH) combination with at least one hydrocarbon (CH) combination, silicon is a very unstable metalloid that is quickly polymerized and this has also limited the concentration of elemental silicon in organic silicons to a maximum of 1 gram. On the other hand, the body can use over 65 % of organic silicon.

The daily requirement to maintain the silicon level in the body at the right level are quite high because it requires a daily intake of 15 - 25 mg of elemental silicon per day for maintenance and up to 40 mg in compensation (collagen restructuring). Most organic silicons contain about 500 mg of elemental silicon and sometimes much less. What this means is that to satisfy the daily requirements mentioned above, you need to consume about 1 liter of Silanol per week at a cost of about 120 €.

Professor ASSOUN and our research teams are aware of this problem and have looked at ways both for stopping the polymerization and for increasing availability. This work has led to the birth of Si-Glycan-3 organic colloidal silicon.

 

2 – SILICON

2-1 Silicon's physico-chemical properties
Silicon (Si) is a metalloid - a metal crystal with reverse optoquantum properties, when means that when it is irradiated by UV radiation, it produces an electric current and, under very specific electrical conditions, it can emit a quantifiable radiation - which as we have seen makes up almost 28 % of the earth's crust (27.7) and this makes it the fourth most abundant element behind hydrogen, nitrogen and oxygen and the second component of the earth's crust behind oxygen. The Swede, Jöns Jacob Berzelius, discovered it in 1824.

In its amorphous form, it is a brown powder; in its crystalline form it is a metallic gray. As a solid, it does not react with oxygen, water or most acids. Silicon dioxide dust (SiO2) is slightly toxic and very irritant. It is 14th in the periodic table and its atomic number is 14 and its valence can be 2 and/or 4. Its atomic weight is 28.0855 amu. Its melting point is1,410°C, its boiling point is almost the double at 2,680°C and its critical temperature is 4,920°C. Its density is 2.32 g/cm3.

The etymology of its name is based on the Latin word silicis meaning flint (which is in fact an impure form of quartz).

It is the main element in clay, granite, quartz and sand. To produce silicon commercially, silicon dioxide (SiO2) is reacted with carbon at 2,000° C. It is used for glass production in the most common form as the dioxide SiO2. Silicon carbide is one of the hardest substances known to man and is used in some polishes. It is used in semi-conductors in its monocrystaline form.

2-2 Mineral form
It is most widespread as the dioxide. In its purest form, the dioxide forms quartz. In this form, the silicon dioxide forms strong bonds with oxygen called covalent bonds where each silicon atom is linked to two oxygen atoms hence the name dioxide for this substance. 

The second solid form in which silicon is found is as silicates. Silicates are the main components of rocks and semi-precious or fine stones.

Silicon oxide is used in the semi-conductor, sand paper and abrasives, glass and cement industries. It is also used as a thermal insulation (refractory furnaces, car spark plugs, etc.)

2-3 Liquid form
The natural liquid form of silicon is ortho-silicic acid, an atypical acid Si(OH)4. This is the form that is present in plants where their chemical processes produce organo-silicates that are used by the plant. However, most of the silicon is oxidized and so only a very small proportion is biologically available.

2-4 Organic silicon
To be called organic, as we have seen, the silicon must contain one or more hydrocarbon groups and these are also called silanes and usually have the following form:
CHx Si(OH)3
It is in this form that it has greatest bioavailability for the body and the hydrocarbon group and the hydroxyl radicals (OH) are both necessary for this.

3 – BIOLOGY AND SILICON

3-1 Silicon and plants
There are certainly multiple sources of silicon in our nutrition and especially in grasses but it is much less present in calcium providing plants or pulses. However, the form in which silicon is present in plants is not readily bioavailable to the body and the same applies to silicon in mineral waters such as Badoit or Salvetat. With 135 mg / liter and total minerals of 3 grams, some mineral waters are even dangerous for the kidneys. In fact, these poorly available minerals (rarely more than 10 %) will condense in the body’s natural filter, i.e. the kidneys, and may be the cause of calculi or other pathological conditions. Furthermore a trial has shown that mineral waters should only be used under medical supervision when they contain more than 1,500 mg of dry matter i.e. mineralisation.

3-2 Silicon and human biology
With more than 7 g in our bodies, silicon is one of the top 10 natural elements found in our bodies. Various studies over the last twenty years have shown the importance of silicon in human biochemistry.

The daily requirement is estimated at 40 mg of elemental silicon. Ingesting 20 ml of Si-Glycan-3 provides 40 mg of elemental silicon and thereby covers this need. Under optimal conditions, silicon can promote better health. However, it is not the miracle treatment that some manufacturers would like us to believe. Organic silicon is a nutritional supplement that is very useful.

3-2-1 Colloidal organic silicon - ossification and joints
Bone and bony tissue have an abundant matrix that encloses sparsely distributed cells. This matrix is made up of about 25 % water, 25 % fibers - mainly collagen) and 50 % mineral salts (Ca). When the salts are deposited on the collagen fibers in the matrix, crystallization occurs and the bony tissue hardens; this process is called calcification or mineralisation. Bone's hardness is due to this crystallization and its suppleness to the presence of collagen fibers. The latter provide more malleability, in other words they make bone less brittle, e.g. an eggshell or oyster shell does not contain these fibers and is much more brittle.
Calcification can not occur unless this collagen is present. Different work has shown the undeniable role of silicon in collagen fiber synthesis where it is also associated with vitamin C.

Furthermore we know that high concentrations of silicon are always found in areas of high calcification: e.g. the extremities of bones that are growing. Its concentration in these sites varies depending on the mineralisation and increases at the same time as it increases. When mineralisation of a site is complete the level of silicon is at its lowest. Silicon therefore appears to be an essential element for bony growth and its deficiency may be a limiting factor, e.g: a chick with a silicon deficiency has skull abnormalities associated with a significant fall in bone's collagen content and abnormalities in long bones and connective tissue.

In cases of bone disease, supplementing with colloidal organic silicon produces excellent results both in terms of the pain reaction and remineralization of the bone. Silicon and calcium work closely together and calcification of fractures can be greatly accelerated by colloidal organic silicon supplements.

Because of its role in bone mineralisation and growth, colloidal organic silicon is an excellent remedy for osteoporosis. Trials conducted on different types of osteoporosis - senile, cortisone induced and post-menopausal - have shown very good results especially for post-menopausal osteoporosis where biological testing of the bony tissues showed a large increase in recalcification. Ageing produces two important skeletal effects: demineralization and a reduction in collagen. The mineral loss starts in women at about 30 year of age and increases between 40 and 45 years old when oestrogens diminish. This process continues with age. In men, the demineralization starts at about 60 years old. The reduction in collagen results in rigid bones, which makes them more susceptible to shocks. Preventive measures can be taken:

3-2-1 Colloidal organic silicon - joints
There are three types of joint: fibrous, cartilaginous and synovial. Their common feature is the presence of connective tissue that contains elastin or collagen. We know of the essential role played by silicon in the synthesis of these two fibers.

Joints must be flexible to allow movement and resist tension. The can degenerate or age prematurely which results in wear and irritation as in arthrosis. Effected joints are usually those that carry the body's weight: spine, hips, knees, feet and some joints in the hand. Arthrosis appears in general at about 46 to  50 years old and its frequency will increase with age if nothing is done. They occur more frequently in women. Arthrosis involves a deterioration of the articular cartilage which has a role similar to a sponge that absorbs shocks. When this disappears, the bones can touch each other and this leads to pain and wear.

Colloidal organic silicon is even able to act in the pain process and cartilage regeneration. Its rapid action on the pain is the first to be perceived. Cartilage regeneration then follows. The greater the decline in our silicon levels the more spectacular the results in terms of pain: rheumatism of the knee, the back or the fingers are soothed in a few days or a few weeks. These results are usually long-lasting: it involves a reconstruction.

In respect of arthritis, which is an inflammation where cartilaginous and osseous lesions follow synovial lesions, with swelling, occasional redness and heat in the joint, there can be a tenfold clinical improvement. Once again colloidal organic silicon is acting on both the pain and the inflammatory processes.

For rheumatoid polyarthritis, an autoimmune condition where the body attacks its cartilages and joint surfaces leading to inflammation, pain and loss of joint function, it is important to treat the condition as soon as possible to avoid fibrous tissue replacing the synovial membrane and blocking the joint. This synovial membrane contains elastin which gives it is flexibility. Colloidal organic silicon acts on elastin production as well as the inflammatory process. Rheumatoid polyarthritis effects 1 % of the population and three out of four people affected are women.

3-2-3 Colloidal organic silicon - cardio-vascular function and the circulation.
Silicon is an integral part of blood vessel walls: its presence is essential for synthesizing elastin and collagen fibers. It therefore helps conserve the elasticity of blood vessels. This property and it contractibility are two important characteristics for the proper function of the blood circulation. Silicon must also be present for vascular tone.

There is a relationship between the concentrations of silicon in the aorta tissue - the aorta is very rich in elastin and collagen fibers - and arteriosclerosis (hardening of arteries causing hypertension). Arteries subject to arteriosclerosis have a silicon level that is much lower than healthy arteries. Silicon helps conserve the integrity of vascular elastin fibers and reduces the permeability of arterial walls; it increases the intra-cellular cement and the thickness of elastin fibers; it also maintains a high level of hyrdolase, the enzyme hat can change cholesterol esters into free cholesterol. Lipid infiltrations within the vascular system are inversely proportional to the silicon levels.

In people with weak venous valves, blood tends to collect under the influence of gravity; this results in an overloading of veins and their walls start to distend. Over time, this wall looses its elasticity, stretches and becomes flaccid. The valve failure leads to a dilated and tortuous vein known as a varicose vein.

Because of its good bioavailability, colloidal organic silicon acts effectively on vascular tone and on the good function of these vessels. It provides the vessels with flexibility and thereby has an indirect effect on blood pressure. Better circulation leads to warming of the skin. Colloidal organic silicon in conjunction with vitamin E is also very useful for eliminating swollen vessels. Blood also carries hormones and their action will be enhanced if the circulation works properly.

Within the cardiac system, connective tissue envelops and separates. It is found in the epicardium that makes up the external layer of the heart. The endocardium that lines the inside of the myocardium lies on a fine layer of connective tissue. It is also connective tissue that divides the myocardium into distinct auricular and ventricular muscle masses. The fibrous connective tissue rings and sheets act as electrical insulation between the auricles and ventricles.

The heart also has valves that stoop backflows of blood. These valves consist of dense connective tissue covered in myocardium. The valves open and close in reaction to pressure changes caused by the cardiac muscle's contractions and relaxations. Most heart problems are related to the coronary artery circulation insufficiencies caused by blood clots or the fatty arteriosclerosis deposits. The presence of silicon, which is a connective tissue component, is the best insurance for maintaining the integrity of cardiac surfaces.

3-2-4 Colloidal organic silicon - muscles and tendons
There are three types of muscle tissue: striated, cardiac and smooth. In this section we are going to look at striated muscle tissue, which is mainly attached to bones but can also be attached to the skin and deep fascias. This muscle tissue is surrounded and protected by fascia, which is a large band of protective fibrous connective tissue. This fascia, called deep, keeps muscles together and separates them into functional groups. It allows the muscles to move freely, transports nerves and vessels and, above all, it fills the spaces between muscles.

Three layers of connective tissue (epimysiumn perimysium and endomysium) extend from the deep fascia to protect and strengthen the muscle; the first envelope protects the muscle, the second protects the fascia of 10 to 100 muscle fibers and the third penetrates to the interior of each fascia and separates each muscle fiber. These three layers extend and provide the collagen fiber for the connective tissue that connects the muscle to the bone. When they extend beyond the muscle, they become a tendon. When striated muscle contracts, it pulls on the tendons and its connective tissue envelops. These are stretched then contract and pull the bone to which they are attached causing it to move.

We have already seen the role of colloidal organic silicon in connective tissue and on its collagen fibers. In this case it provides flexibility and mobility to muscles and tendons. It also helps eliminate pain.

Another fascia called superficial fascia is found between the skin and the deep fascia of the muscles; it is called the sub-cutaneous layer. It consists of loose connective tissue and has several functions; it stores water and fat, forms an insulating layer that prevents loss of body heat (don't forget that muscle contractions generate up to 85 % of body heat), protects the body from external shocks and allows blood vessels and nerves to enter and leave muscles.

Through its percutaneous action, colloidal organic silicon helps strengthen some of the superficial fascia's functions. It provides better protection against the impact of climatic damage: humidity, cold, rain, and pressure changes. Silicon provokes an increase in the number of red blood cells, which indirectly results in better oxygen transportation, and muscles consume large amounts of oxygen when working. It can therefore produce better performances.

3-2-5 Colloidal organic silicon - intervertebral discs
Intervertebral discs act as shock absorbers: they are constantly being subjected to compression. Each disc is made of an external ring of fibro-cartilage - called the anulus fibrosus - and a soft internal structure that is pulpy and very elastic, the nucleus pulposus. The discs form good joints that allow a range of movements for the spine. Their role is also to absorb vertical shocks by being compressed: they become flattened, enlarge and spread out in their intervertebral spaces.

It is known that the cartilaginous tissue contains up to 100 mg / kg of silicon in fresh tissue. The body' silicon content reduces as we discussed earlier due to its poor bioavailability for man. However we need silicon to renew our cartilage. It ensures the integrity of our cartilaginous tissues, nourishes them and stimulates collagen production. The fibro-cartilage is rich in networks of collagen fibers whilst the nucleus consists of elastin fibers. Colloidal organic silicon through its high bioavailability acts effectively on the regeneration of intervertebral discs.

3-2-6 Colloidal organic silicon - the skin
We are not telling anyone anything original when we say that the skin owes its flexibility to the presence of special collagen fibers that are poorly renewed as we get older, which results in a slackening of the cutaneous tissue, wrinkles, etc. Using exogenous collagen has several drawbacks, firstly the cost and the very poor rate of collagen recuperation by the body. Furthermore, using exogenous collagen can have an asphyxiating effect on the skin and can stop it from respiring and, in the long term, may lead to local cancers. Colloidal organic silicon supplementation on its own or in conjunction will help maintain the amount of collagen fibers and thereby delay skin ageing without having the disadvantages of the products mentioned above. 

3-2-7 Conclusion
Silicon has multiple roles within the body as we have seen. Apart from its involvement in many biochemical reactions, we can consider that it is also a potentialiser for other metals and metalloids; it would appear that this is how silicon works as a co-factor in some enzyme reactions (Enzyme Metal Substrate). Its role in protecting glycan-proteins (proteins on the cell surface) should not be forgotten either. Colloidal organic silicon supplementation can be considered as a nanonutrition supplement at several cellular levels that allows the body, through clearing out some stored aberrations, to be more receptive to other treatments. In this sense, we can consider a silicon supplement as having an impact on many pathological conditions. Finally, the anti-free radicals effect of silicon appears to be established and at the same time this confirms its broad anti-ageing effect on the body.

 

4 – SILICON AND THE LAW

4-1 The precise concentration of elemental silicon in organic silicon.
Without starting an advanced chemistry course, we understand that in the standard formula CHx Si(OH)3 only the Si element matters and that we want to provide the body with 25 mg of silicon (Si). As a result, what matters is not the organic silicon content but the amount of silicon element. Taking as an example the standard formula: CH3 Si(OH)3

It has the following atomic weight:
the atomic weight of 1 carbon atom: 12.0107
the atomic weight of 3 hydrogen atoms: 3.02382
the atomic weight of 3 pairs of oxygen and hydrogen atoms: 17.00734 x 3 = 51.02202
the atomic weight of 1 silicon atom: 28.0855

This gives us an atomic weight for the molecule of 94.34022 where elemental silicon represents only 29.77 %. The calculation that then follows is simple; 1 g of this molecule contains 297.7 mg of elemental silicon, which is almost the same as the daily requirement for a dozen days. This explains why the percentage organic silicon does not means anything either scientifically or in terms of consumer information content.

Lets go back to our calculation: e.g. for 0.2 % organic silicon CH3 Si(OH)3, 1 liter will contain 595 mg of elemental which means that 30 ml / day will provide 17.86 mg x 65 % (absorption coefficient) = 11.61 mg, or 46.44 % of the recommended daily intake and we are not looking at a situation of compensation when this daily requirement can be as high as 40 mg.

The molecule developed in our laboratories has a concentration of 2 g of elemental silicon per liter which, if we were using the standard molecule, would be equal to almost 7.5 g of organic silicon, which provides a maximum supplement of this essential element and at a consumer price that is only a quarter of that paid for similar supplements.

All this is nothing more, in reality, than an explanation of the law on nutritional supplements containing metals or metalloids that requires that their exact concentration in elemental terms is indicated. It is surprising that consumers, who are used to seeing this information on the packaging of products such as magnesium or trace elements, do not appear to take this into account when looking at silicon.

4-2 Product labeling for products containing metals or metalloids
The European law requires that the amount of elemental metal contained in the product be shown on the label in mg or ug. Theoretically, this weight should be shown for all the components, for a dose and for the daily supplement recommended by the producer. In fact, stating the content of silanes on the product has no scientific value as we demonstrated above. It is also because of this imprecision on the label that no silane is recognized as a nutritional supplement. In Europe, only colloidal silicon has this designation. It is also due to the current legislation that we have developed a silicon that satisfies both the organic and colloidal requirements which makes it a product that can be referred to as a nutritional supplement.

 

5 – SILICON PRODUCT RANGE

Si-Glycan-3 colloidal organic silicon  (drinkable nutritional supplement or for external use)
concentration: 2 grams elemental silicon / liter
presentation: two half-liter bottles

Colloidal organic silicon gel (for external and base use)
concentration: about 60 grams elemental silicon / kg
presentation: 80 grams jar

Arthrosil Si-Glycan-3 (drinkable nutritional supplement or for external use)
concentration: 2 grams elemental silicon / liter and 20 grams glucosane sulfate / liter)

Arthrosil Si-Glycan-3 gel (for external and base use)
concentration: about 60 grams elemental silicon / kg + glucosamine sulfate.
presentation: 80 grams jar

Gel d'Arthrosil +  (for external use)
as above + 10 % essential oils

AloeSil Si-Glycan-3 (drinkable nutritional supplement or for external use)
concentration: 1 gram elemental silicon / liter + organic Aloe vera
AloeSil+ Si-Glycan-3 gel (for external use)
concentration: about 60 grams elemental silicon / kg + organic Aloe vera

AloeSil+aroma gel (for external use)
as above + 10 % essential oils

Our laboratories guarantee:
The traceability of the components, their innocuity, their efficacy supported by the professionalism of a European laboratory.

NOTA BENE:
All our products are nutritional compliments or supplements or cosmetics and should not be considered as medicaments under any circumstances. We do not accept any responsibility if our products become denatured.